天津招聘

Frontage Lab ADME Senior personal Job description:

    

    

Our Client is seeking a Head of ADME with expertise in drug metabolism and pharmacokinetics (DMPK) to be based in Shanghai or Suzhou, China. This candidate will represent as an ADME Project Leader, with responsibility for guiding DMPK related activities on early drug discovery and drug development.

    

    

Scope of the Job. 

    

1. Design and implement aggressive, innovative preclinical ADME plans for drug discovery projects.

    

2. As a subject matter expert, work with project teams, and external experts to develop a strategy for identifying and solving issues in ADME area.

    

3. Integrate in vitro, in vivo, and in silico ADME data with discovery biology and medicinal chemistry to define structure activity relationships to drug design strategies and help optimize drug properties.

    

4. Interact across groups, including other departments, regulatory agencies, and functional groups within drug disposition.

    

5. Responsible for the design, oversight, interpretation, and reporting of preclinical study results.

    

6. Design/execution of preclinical PK/PD studies.

    

7. Lead internal and collaborative research to increase mechanistic understanding of clearance pathways and/or drug distribution and improve translatability of preclinical models.

    

8. Prepare preclinical data packages and regulatory submissions to enable clinical studies.

    

    

Skills and Education. 

    

1. Ph.D. degree in Drug Metabolism, Pharmacokinetics, or Pharmaceutics, or an advanced degree in a related science with extensive training in the field of drug metabolism and disposition.

    

2. At least 5 years of direct experience in drug discovery.

    

3. Excellent verbal and written communication skills, with fluency in English.

    

4. Strong background in one or more of the following: pharmacokinetics, PBPK modeling, transporters, or drug metabolism.

    

5. Strong interpersonal and team-building skills, including demonstrated experience working in a team environment.

    

6. Experience working with external contract research organizations.

    

7. Medicinal chemistry expertise.

    

8. Proficiency with PBPK software (e.g. SimCYP or Gastroplus).

    

9. Regulatory experience, including Pharm/Toxicology experience at a regulatory authority.

    

方达医药全球型全方位新药研发外包服务公司（CRO）,于2001年成立于美国，总部位于宾夕法尼亚州费城西郊的埃克斯顿。2006年成立方达医药技术（上海）有限公司，在苏州和郑州分别设有分公司和管理团队。2019年5月30日，方达控股（方达医药上市主体）成功登陆香港联交所主板，股票代码*******。

方达医药始终坚持“中美两国，同一质量体系”准则，获得数据可用于全球申报，目前已为全球400多家客户提供高质量、高标准的新药和仿制药研发服务。作为中国制药企业国际化及高端药物研发合作伙伴，方达医药拥有技术熟练的专业团队，配备了国际最先进的药物研发仪器和设备，并努力为客户创造友好轻松的合作和沟通环境。专注于一体化的专业服务，业务范围包括生物分析、BE临床服务、CMC药品制剂研发、cGMP咨询及国际药品注册等服务项目。

● 我们为员工提供全面的福利待遇，并履行对员工健康和福利的全面承诺。
● 我们为员工提供了与***制药公司合作的机会，让其成为药物开发过程的关键贡献者。
● 我们为员工提供良好的职业发展机会，确保员工在行业内不断积累经验。
● 我们的员工是最有价值的资产，我们拥有明确的员工奖赏计划，肯定员工的奉献精神，奖励员工的辛勤付出。

您也可以发送简历至招聘邮箱：recruitment@frontagelab.com.cn
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