杭州招聘

Bota Bio is looking for a distinctive Scientist to join our Strain Development team. The Scientist will be responsible for developing alternative hosts for producing recombinant proteins in therapeutic applications. The Scientist will work collaboratively with other research staff to engineer cell lines, identify and derisk bottlenecks, and develop new technologies to deliver against project milestones. This is an opportunity to participate in commercial manufacturing while shaping the platform of the future in a dynamic company.
Job Description and Responsibilities
- Engineer metabolism and other biological aspects to boost the production of functionally active proteins.
- Develop genome editing techniques for a wide range of microbial chassis (e.g., bacteria, yeast).
- Generate rational or random strain libraries using combinatorial multiplexed methods as appropriate.
- Apply high-throughput analytical methods to facilitate bulk genotyping/phenotyping of genetic variants.
- Work with in-house robotic automation and software infrastructure for LIMS data tracking.
- Improve workflow efficiency for better economics, equipment utilization, and turnaround time.
- Contribute to the selection of protein-based biologics in a wide variety of application areas.
Experience and Qualifications
- We favor candidates with a Ph.D. and strong track record in some of these areas: protein biologics (antibody engineering techniques, therapeutic protein/peptide production, protein glycosylation), metabolic engineering (bioreaction/pathway design, flux balance analysis, analytical chemistry), molecular biology (DNA assembly, NGS sequencing, microbial genome editing), or related fields.
- Experience with visualizing large amounts of data; using scripting is preferred (e.g., Python, SQL).
- Having good communication skills, highly collaborative in a team setting. Working conscientiously with a strong sense of work responsibility. Comfortable with speaking and writing in English.

Bota Biosciences恩和生物坐落于杭州钱塘新区的新加坡科技园，是一家合成生物学技术开发商，公司基于合成生物学理念，通过利用标准化、自动化的高通量生物制造平台（Bio-foundry），结合生物信息计算和机器学习对生物体进行系统性、工程性编辑，致力于开发 高效、绿色、低成本，且适用于大规模生产的工业生物制造技术，并为化工、食品、制药和农业等多种产业提供关键技术解决方案。
公司创始及核心团队成员由来自MIT、哈佛大学，以及Amyris、Ginkgo等合成生物学领域的奠基公司的多位学界和业界专家组成，团队拥有丰富的产业开发经验。目前，公司专业能力囊括生物计算、菌株工程以及发酵工艺，覆盖了从产品研发到大规模产业化的全过程。目前公司已成为国内合成生物学领域的头部公司，于2020年11月成功入选《麻省理工科技评论》50家聪明公司。