广州招聘

职位描述：
POSITION DETAILS

POSITIONNING

Biodevelopment Asia: Analytical Process development Scientist Junior

PURPOSE OF THE ROLE
Within the Biodevelopment Process Development group, will execute projects including developing, validating and transferring chromatographic methods for biotech molecules. Execute client project according to budget and timelines given to the project team.
Develop, validate and transfer robust analytical methods required for successful drug development and manufacturing.
Support follow-up and throubleshooting on analytical methods.
Support process and pharmaceutical development with chromatographic methods, technical expertise and solutions.
Compile and analyze experimental data to generate process knowledge and decide on next steps
Write development and validation reports and ensure their timely delivery
Prepare and present project updates to global project team and to upper management


KEY RESPONSIBILITIES


PROBLEM SOLVING
? Background on chromatographic techniques applied to Biomolecules;
? Good knowledge on biotech processes development, protein purification and formulation.
? Consolidated knowledge on protein chemistry and direct experience on protein analysis by chromatographic, electrophoretic, spectroscopic and mass spectrometry techniques
? Excellent knowledge of analytical development of chromatographic methods, validation, tech transfer and applied statistics;
? Knowledge of common and specific software in use in analytical labs;
? Responsible for biophysical characterization of proteins:-
o Execute routine protein purification with affinity, size exclusion, ion exchange, and hydrophobic interaction chromatography using AKTA systems (Unicorn software)
o Perform analyses including but not limited to SDS-PAGE, SE-HPLC, LAL, host cell-DNA, host cell protein, as necessary
o To develop, validate and transfer robust analytical methods required for successful drug development and manufacturing.
o To support follow-up and throubleshooting on analytical methods.

AUTONOMY
- Manage his own organization in order to optimize his activities (cost & deadlines)
- Plan experiences under his responsibility
- Report activities & results to his manager
- Ensure coordination with project managers, technical lead, his manager


MAIN INTERFACES
INTERNAL :
USP, DSP, QA & Reg, production, Technical leaders & project managers. Other Biodevelopment teams worldwide
EXTERNAL :
Group ？ Other process development & production team & project managers, teams from research & R&D
Outside of Group ？ Suppliers, universities, external companies in research or & development fields.


EDUCATION AND EXPERIENCE

? Bsc/Msc in biotechnology with 2-5 years in the biopharmaceutical industry
? Solid theoretical basis and hands-on experience in protein characterization.
? Experienced in protein purification via affinity, hydrophobic interaction (HIC), ion exchange (IEX), size exclusion (SEC) and mixed-mode chromatography
?
? Knowledge and skills in biochemical characterization of proteins including analytical and biophysical techniques. Experience with protein formulation strategies is highly desirable.
? Solid working knowledge of DOE. Ability to critically analyze data using statistical tools and to compile technical reports
? Good presentation and communication skills
? Results-oriented with ability to work and deliver under pressure
? Excellent English (written, oral) 举报 分享

Merck – Living Innovation
默克 – 创新引领生活

默克是一家全球领先的医药与化工公司，以创新和高科技优质产品闻名世界。

默克在全球66个国家与地区拥有约38,000名员工，致力于改善患者的生活质量，助力客户实现长远的成功和迎接全球化挑战。

默克旗下四大业务分支——默克雪兰诺、消费者健康、功能性材料和默克密理博——2012年总收入达112亿欧元。

默克是全球历史最悠久的医药与化工公司。自1668年起，默克就成为了创新、成功和负责任的企业家精神的代名词。默克家族作为公司的创始人至今仍持有默克大部分的股份。

我们是默克，正根正源，在全球拥有“默克”这一名称和品牌的所有权。唯一的例外是在美国和加拿大，我们使用“EMD”的名称。
Merck – Living Innovation

Merck is a leading company for innovative and top-quality high-tech products in the pharmaceutical and chemical sectors.
Around 38,000 employees work in 66 countries to improve the quality of life for patients, to further the success of our customers and to help meet global challenges.
We generated total revenues of