北京招聘

Responsibilities:职位责任：
1.    In charge of antibody humanization, affinity optimization, antibody characterization for developability analysis.
负责抗体人源化，抗体亲和成熟, 抗体表征验证与成药性分析。
2.    Antibody homology modeling and protein simulation by multiple protein analysis software is preferred.
抗体结构分析，使用多种抗体结构专业分析软件进行分子建模和空间构象分析。
3.    Expertise in protein expression and protein purification in mammalian systems, familiar with FPLC/HPLC, ion-exchange, etc.
抗体蛋白表达及纯化。
4.    Keep a close watch on the leading-edge developments of therapeutic antibody and immunotherapy; understand global and local therapeutic antibody markets. Be involved in new drug development strategy setting up and targets exploration.
及时跟踪和了解国内外药物发展动态，参与制定项目的开发策略。
职位要求：
Requirements:任职要求：
1.    Ph.D. degree in bioinformatics/computational biology/protein engineering related fields.
要求具有抗体工程，计算机生物学或有抗体结构分析经验背景的博士。
2.    Strong expertise at antibody humanization, affinity optimization, antibody characterization for developability analysis, e.g. PTM optimization, homogeneity, TM, stability etc.
熟悉抗体人源化，抗体亲和成熟, 抗体表征验证与成药性分析，例如，PTM位点优化，TM，同质性，稳定性分析等。
3.    Familiarity with protein expression (mammalian cell expression system) and protein purification (purification of tagged or untagged protein from cells or organisms by FPLC/HPLC systems, experience in purification of engineered protein and transmembrane protein).
熟悉真核重组蛋白表达系统，优先考虑具有蛋白表达与纯化经验者。
4.    Excellent skills in problems solving, proficient in communication in English and English writing. 具备很好的分析解决问题的能力，以及英语读写沟通的能力。
5.    Ability to work in collaborative environment and contribute to team projects. Ability to work without close supervision and enjoys working with other people within an international team and in a dynamic environment.
具有强烈的责任感、很好的沟通能力和团队合作精神。
6.    Strong background of tumor biology is preferred.
具有肿瘤生物学背景者优先考虑。

百济神州是一家立足于科学的全球性生物科技公司，专注于开发创新、可负担的药物，旨在为全球患者改善治疗效果，提高药物可及性。目前公司广泛的药物组合包括40多款临床候选药物。公司通过加强自主研发能力和合作，加速推进多元、创新的药物管线开发。我们致力于在2030年前为全球20多亿人全面改善药物可及性。百济神州在全球五大洲打造了一支超过8,000人的团队。