北京招聘

  

Provide bioinformatics support to antibody discovery:

• Large scale sequence analysis for antibody libraries;

• Antibody structure modeling and analysis;

• Ad hoc analysis requests from project teams.

• Develop bioinformatics tools to assist scientists’ research activities.

• Develop algorithms for predicting antibody developability properties.

Develop IT infrastructures to support data analysis and management:

• Develop databases for sequence or molecule registration, sample inventory, characterization data;

• Develop applications to support antibody screening workflows and data analysis;

• Develop applications to support protein production workflows.

General IT support:

SharePoint site maintenance;

Company website maintenance;

Intranet net drive maintenanc

Qualification and competency requirements:

  

A. Education/training background:

  

• Master / PhD in bioinformatics or computational biology;

• or Master / PhD in wet-bench life sciences with experiences of informatics, software engineering or data science.

• At least 2 years working experience in pharmaceutical or biotech companies is required.

      

  

B. Knowledge/Skills:

  

• Mastery of at least one programming language (e.g. Perl, Python, C++/C#, Java) is required. Experience on BioPerl or BioPython or BioJava is plus.

• Unix/Linux environments, Unix/Linux command line tool knowledge are preferred. Experience on Unix/Linux system administration is preferred; knowledge on distributed computing environment is plus.

• Knowledge of data storage and access technologies including SQL is required. Experience of database design and database administration is plus. Experience of MySQL system is plus.

• Experience of Web application development is plus.

• Experience of LIMS system development is plus.

• Working knowledge of standard bioinformatics resources and databases is required.

• Experience of Sanger sequencing data analysis is plus.

• Experience of Next-Gen Sequencing data analysis is plus.

• Knowledge of antibody sequence, structure and function is plus.

• Experience of antibody repertoire analysis is plus.

• Experience of protein structure modeling is plus.

• Experience of data acquisition, processing, transformation, analysis and visualization is plus.

• Experience of machine learning and algorithm development is plus.

• Experience of following software / tools is plus:

  • Molecular biology: VectorNTI, SnapGene, CLC Workbench, etc.,

  • Data analysis and process: Origin, GraphPad Prism, R, Spotfire, etc.,

  • Structure analysis: PyMol, CCP4, UCSF Chimera, etc.,

  • Structure modeling: Rosetta, MOE, Schrodinger, Discovery Studio, etc.,

• Knowledge of molecular biology or protein chemistry or structure biology is plus.

• Knowledge of work flows in drug discovery is plus.

                                          

C. Others:

  

• Good planning and execution skills to meet deadlines and to handle multi tasks.

• Quick learner and good team player.

• Strong problem-solving skills.

      

和铂医药是一家专注于肿瘤免疫领域创新药物研究与开发的全球化运营生物医药公司。公司将运用其拥有的全部自主知识产权的全人源单抗的转基因鼠系列核心技术平台，建立下一代治疗性肿瘤抗体药物产品管线,并将围绕Harbour的两大平台拓展合作与授权业务。公司总部及研发基地位于中国上海，另外在美国马塞诸塞州剑桥设立商业运营中心，在荷兰鹿特丹设立抗体研发平台创新中心，在波士顿地区设立了创新中心包括实验室和研发团队，也将在江苏昆山设立研发基地。公司拥有资深管理团队以及丰富的药物研究与开发经验。和铂医药要为满足中国及全球病人的需求而不断努力，依托拥有自主知识产权的核心技术平台,创建一个在肿瘤治疗领域有科学与技术领导力的国际性生物医药公司。同时, 在药物研发领域建立以技术平台为基础的对外合作，整合新的技术，推动中国整个抗体研发产业的进步。

Company Overview
Harbour BioMed is a global biotechnology company discovering and developing innovative therapeutics for cancer with a focus on immuno-oncology and autoimmunity/inflammation. The company's discovery and development programs are centered around its two patented transgenic mouse platforms for human antibody discovery.
The company is building its proprietary pipeline internally, through collaborations with co-development partners, as well as through selective preclinical and clinical stage asset acquisitions. Harbour BioMed also licenses the platforms to companies and academic institutions through its Harbour Antibodies subsidiary.
Harbour BioMed has headquarters and an R&D site in Shanghai, business operations in Cambridge, MA, and antibody platform development in Rotterdam, The Netherlands.
The company has an innovation center including research lab and a development team in Boston. Also, we are expanding to Kunshan site in Jiangsu for our R&D operation.